In 2006, the US Food and Drug Administration (FDA) issued a warning regarding oral sodium phosphate use in high risk patients. Members will discover new information and solutions to assist them with their treatment. Its also essential to have a healthy mindset, especially when you are going through treatment. 3 The timelines and procedures can vary, but here is an example commonly used for a colonoscopy bowel prep: Upon waking, eat or drink nothing but clear liquids. The day before. Colonoscopy Prep For Chronic Kidney Disease. A high-quality and safe colon cleansing preparation is important for colon cancer screening using colonoscopy. What to do if you experience discomfort while preparing for bowel surgery. Significant fluid and electrolyte shifts are therefore attenuated. Q. This has worried both doctors and patients as they chose a colonoscopy prep. Save my name, email, and website in this browser for the next time I comment. So you can have the complete scope of the digital product. They have a team of qualified specialists to ask any questions regarding your concerns about the program. Unconscious patients. The recommended dose of OsmoPrep for colon cleansing for adult patients is 32 tablets (48 grams of sodium phosphate) taken orally with a total of 2 quarts of clear liquids in the following manner: The evening before the colonoscopy: Take 4 OsmoPrep tablets with 8 ounces of clear liquids every 15 minutes for a total. Host an Event. Everything in the program was carefully researched and selected to guarantee the best results for people over 60. These cookies will be stored in your browser only with your consent. Thank you for your comment. Help families facing kidney Patients with chronic kidney disease are more likely to develop acute phosphate nephropathy after using oral sodium phosphate. It will also depend on their specific requirements. All of these are available digitally. Furthermore, proper sedative and bowel . Talk to your primary care doctor about when to start having Your support helps families facing kidney, People who know they have chronic kidney disease, People who have bowel obstruction, delayed bowel emptying, active colitis, People taking certain medications. Yes. Phase 1 will be focusing on The Essentials. Phase 2 contains how to treat your cause, while Phase 3 will cover treatment protocols for symptoms and other ailments. "We know it works. Don't eat any solid food. Within six months during her treatment, she transferred from stage-4 to stage-1. Several better-tasting and lower-volume It works best for people who have limited access or options to take care of their kidney disease. All the treatments theyve included are based on the latest developments from several research and studies. The Kidney Solution costs $87 the entire collection. 134 Park Central Square #210
The FDA warning is for bowel cleansing agents called sodium phosphate (OSP) products. This can be helpful with your healing, and it also helps you to practice mindfulness. Although the other options require that the patient consume a gallon of liquid, sodium phosphate bowel cleansers require less (about a quart and a half) and they can be taken in tablet form, which requires less liquid yet. Your only options are either to prevent them until you reach the point where you will need dialysis, or worse, kidney transplant. You will only have to make a one-time payment fee. Osmoprep tablets and Suprep should not be used if you have heart or kidney problems. This category only includes cookies that ensures basic functionalities and security features of the website. This can be helpful with your healing, and it also can help you to practice mindfulness. You will be using a Miralax and Magnesium Citrate preparation to clean out your colon. Choose a PEG-based bowel cleansing. The time it takes to get to this point . Two-thirds were women, and none had a history of kidney disease. Information provided by (Responsible Party): Chi-Liang Cheng, Evergreen General Hospital, Taiwan. That means you can have the full scope of the digital product. You can also decide to add $27 for the Gold pack. Afterward, youll want to read the rest of the article for a more comprehensive review. There arent any side effects since the remedies they used only involve natural medicine. Polyethylene glycol (PEG) is the most commonly used bowel cleansing agent for colonoscopy in the world. I have no family history of kidney problems or even diabetes. Hi Julieann, Was your doctor able to tell you why you had the worst UTI of your life following your colonoscopy? You can also get in touch directly with the co-creators of this program. . The colonoscopy investigation The patients returned within 28 days after the colonoscopy for a final renal safety evaluation (visit 3). Dont worry since this is harmless for people over 60. These can be used as laxatives as well as in preparation for colonoscopy. Fax (919) 854-0049 . Healthy patients might be tempted to take the slightly easier route, unaware that they may actually have some kidney dysfunction and could wind up paying a price. All the treatments theyve contained are based on the latest developments from multiple research and studies. You can access the materials on any device. Cleansing the colon before a colonoscopy is called bowel preparation, or "prep.". not . Your email address will not be published. Just prior to the colonoscopy I had a blood test that showed no problems with kidney function. . Patients with a 30% increase above the baseline serum creatinine levels during visit 2 or 3 were followed every 2-4 weeks until a peak level of creatinine was detected. Your email address will not be published. But sorry to hear you had kidney stones. In just 12 weeks, her condition improved significantly. It will also depend on their specific requirements. The afternoon or evening before the colonoscopy: Drink the first dose of the prescribed laxative preparation. The afternoon or evening before the colonoscopy: Drink the first dose of the prescribed laxative preparation. Manufacturers advised caution with use of Suprep, Clenpiq and Prepopik in patients with kidney disease. Youll also understand what steps you need to choose based on factors like symptoms, specific causes, and conditions. We believe that guidelines are necessary because the risk of complications depends on the choice of bowel preparation and . Two days before your exam, you'll . Your age, race and family history will affect the Sodium phosphate should not be used in patients with preexisting serious renal disease, adequate hydration should be assured in all patients, and renal function should be monitored before and after colonoscopy in those at risk of renal dysfunction.SOURCE: Russman et al, American Journal of Gastroenterology, Early Online Articles, October 26, 2007. To examine risks associated with use of the phosphate products, the authors analyzed kidney function among 268 patients at their clinic who had undergone either a colonoscopy or sigmoidoscopy between 1998 and 2005. The Kidney Disease Solution has treated over 25,000 people globally since 2008. If colon polyps are removed, colon cancer is decreased. Nevertheless, "we believe that PEG preps are a safer option for patients" until further testing is done, he said. Certain prerequisites should be met before the procedure for a successful and safe colonoscopic examination.1,2 The reason for the colonoscopy should be checked, as well as the patient's concurrent medication and general health condition. You can make a choice that meets your personal needs. Moreover, theres a cookbook included. So from the start, they know people in that group will most likely use it. Yes the drugs do affect the kidneys Dr.Lynda A. Szczech, MD, MSCE (guest speaker) confirmed. There are other FDA-approved alternatives to OSP for bowel preparation prior to colonoscopy that may be safer for some patients, but may not always clean the bowel adequately. Through their holistic approach, they encourage you to do meditation yoga and exercises. program that can help improve your kidney function, How to Boost Your Kidney Test Result Guide. The topic of the drugs used to prep for colonoscopy came up. Your only choices are either to prevent them until you arrive at the point where you will need dialysis, or even worse, kidney transplant. The Kidney Disease Solution approaches each treatment holistically. Contribute to our mission with a general, memorial, or honor donation. regular colonoscopies. COLONOSCOPY PREPARATION FOR PATIENTS ON DIALYSIS A high quality and safe colon cleansing preparation is important for colon cancer screening with colonoscopy. Some over-the-counter medicines for pain or fever might also lead to increased risk. Of course, the lower-volume preps require additional clear liquids for action. -- Stephen B. Erickson, M.D., nephrology, Mayo Clinic, Rochester, Minn. Medical Edge from Mayo Clinic is an educational resource and doesn't replace regular medical care. Patients receive blood tests for renal function and electrolytes before and after colonoscopy. Ended up in the ER Friday eve w bilateral stones. Colon cancer is treatable when the disease is caught early and the best treatment is to identify and remove precancerous polyps before they progress to cancer. A person's kidney function could go down to 20 to 25 percent of normal, and yet he or she might feel perfectly well. Symptoms of acute phosphate nephropathy are: Early on, people may not have any symptoms at all. The guided meditations are available in audio format. Heres a quick overview of the three phases. The stages are based on estimated glomerular filtration rate or eGFR. If the body is too acidic, this process may cause the loss of valuable alkaline minerals such as calcium, magnesium, and potassium. The dose for colon cleansing requires administration of two bottles of SUPREP Bowel Prep Kit. There are an array of specific organic remedies that you need to take daily to treat your problem. Khurana pointed out that the safety risks he observed might ultimately be the result of patients simply not following manufacturer instructions to drink large amounts of clear liquid when consuming the preparation. Its a terrific program that can help improve your kidney function, even if you are already diagnosed with chronic kidney diseases. It is possible that phosphate crystals might be deposited in the kidneys when these products are used by some people. You can send an email to support@beatkidneydisease.com. Olive oil. Cleveland Clinic 1995-2023. Colonoscopy Prep Chronic Kidney Disease. These patients include those with kidney disease, liver disease, heart failure, high blood calcium, and elderly patients over the age of 55. Theyve included meditation audiobooks as well as a few of yoga videos to follow. Some 5 to 10 percent of the U.S. population is estimated to have less than 60 percent of normal kidney function. NEW YORK, Oct. 18 - Patients having a colonoscopy often object to the bowel prep most of all, and now it appears that there's another good reason to dislike it. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. In patients over the age of 75, 6.8% will suffer a complications within 30 days. These agents work by causing fluid loss so patients are recommended to drink large quantities of clear liquids as part of the bowel preparation. Hi Gaurav, Thank you for your comment. Hi Kelley, Were glad you had your colonoscopy! If you have a colon, you are at risk for colon cancer. comparing 45 and 90-ml oral sodium phosphate with X-Prep in the preparation of patients for colonoscopy . Ask your doctor if you are taking diuretics, angiotensin converting enzyme [ACE] inhibitors, angiotensin receptor blockers [ARBs], and inflammation and pain relief medications such as nonsteroidal anti-inflammatory drugs [NSAIDs]), Add a black boxed warning to the pharmacy package insert for these products, Develop and distribute a medication guide for patients that is easier for most patients to understand than package inserts, Arrange a post-marketing trial to assess the risks to patients taking OSP products. In one trial, 91% of patients rated Sutab as very easy to tolerable to consume, and 78% said they would request Sutab again for a future colonoscopy. When youre not sure of a healthcare providers credentials, ask about their complication rate, completion rate and adenoma (polyp) detection rate before having a colonoscopy, she says. "People should be very cautious in the use of these agents because of their potential of causing kidney damage," said study author Dr. Anand Khurana, of the department of nephrology with the Scott & White Clinic at Texas A&M University in Temple, Texas. found to be safe and efficient for this purpose in multiple studies in selected patients. Khurana and his team found that its use was associated with a 6 percent drop in kidney function six months later; that figure rose to 8 percent one year later. The screening visit (visit 1) induced a blood specimen for serum chemistry analysis. Bowel cleansing is a common almost routine procedure that is used in ambulatory as well as in hospitalized patients in preparation for abdominal surgery, radiological examination of the lower gastrointestinal tract and colonoscopy. The American Society of Gastrointestinal Endoscopy offers a list of questions that you can ask. The entire collection is available in their official site. Some high-risk groups are encouraged to begin undergoing screenings at an earlier age. The organization estimates that about 150,000 people will develop the disease this year alone. Being able to understand what your current situation is can be helpful to create a good action plan. Colon cancer arises from colon polyps. Can you tell us more? One recent population-based study reported that the use of PEG was associated with an increased risk of acute kidney injury. Do not schedule colonoscopy on the same day as your dialysis. To summarize, The Kidney Disease Solution includes all you will need to know about kidney therapy. They have even included a cookbook for you to follow. In the program you'll find a collection of ebooks and cookbooks. You may send an email to support@beatkidneydisease.com. A person's kidney function could go down to 20 to 25 percent of normal, and yet he or she might feel perfectly well. ^{R!]hFW`~9bJ,4<7jp hpj(}4
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{Fv@G98~ hnVrq~yCn6_GSZ}hxWqc8]mymyjUh>,fm Suite 204 . You dont need to follow each of the available therapies and the different diet programs. If youre not sure if this will work for you, do not worry. The death rate continues to drop, thanks to early screenings and better treatment. In 2006, the U.S. Food and Drug Administration put out an alert on oral sodium phosphate products, excluding OsmoPrep, recommending that they be "used with caution" among patients with impaired kidney function due to its high phosphate content. SUPREP Bowel Prep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults. The studies they based their treatments are conducted worldwide and are ultimately focused on kidney health and kidney therapy. www.centerfordigestivediseases.com . Their team promises to give you a full refund if you are not satisfied with their program. Dr. Burke says liquid bowel-cleansing agents have become Most were white, with an average age of 68. Individuals will need to treat their condition based on their kidney disease case. Its made to safeguard you from adding damage to your kidneys so that you can avoid transplant and dialysis. That's why doctors advise drinking as much liquid as you can during and after the prep, be it in the form of water, clear Gatorade, white . Dehydration is probably the most common side effect of colonoscopy prep, because so much fluid is lost via the bowel cleanse. However, the majority of them dont know it until its too late. Oral sodium phosphate should be avoided in patients with chronic kidney disease. reCAPTCHA helps prevent automated form spam. Topics like kidney ailments, diagnosis processes, and even their causes will be covered so that you can understand whats going on in your body. Those with a gastrointestinal obstruction that will prevent passage of liquid into the intestine. They looked for another solution rather than having her undergo dialysis. There are 2 types of dialysis-hemodialysis and peritoneal dialysis. On the day of the colonoscopy only consume clear liquids up to two hours prior to colonoscopy. Along with the half-gallon and split-dose Patients should discuss the risks of the preparation and procedure as well as the benefits of the screening to determine the best bowel cleaning agent for their age and risk conditions as noted above. These cookies do not store any personal information. If you are scheduled for a colonoscopy, you need to discuss your medical history and the drugs you are taking with the doctor who will be performing the test. I%+T'e%6}i"8=BC~#T\*zYB$O#.gwL.EVXJ7n0[~d!)g+Q1\U*`6{E]KF?cC1PbKEc=b
7SXO("+ xR. New research suggests the risks of oral sodium phosphate solution and some oral sodium phosphate tablets are rare but real, particularly for elderly patients. This can damage the kidneys in two ways: by clogging some of the organ's ducts and by disabling some kidney tissue, which is essential for filtering toxins from the blood. E-mail a question to medical edge@mayo.edu, or write: Medical Edge from Mayo Clinic, c/o TMS, 2225 Kenmore Ave., Suite 114, Buffalo, N.Y. 14207. Dr. Hemant K. Roy, an associate professor in the department of medicine at Evanston-Northwestern Healthcare in Illinois, described the findings as "quite alarming" in an accompanying editorial. Antonella Milo, a world-renowned yogini, teaches it. Stress can aggravate your condition, and it can badly affect your overall health. Significant fluid and electrolyte shifts are therefore attenuated. }:8sph
;zeN?==_N?Vb_?faO?W[ It also include patients taking certain medications like NSAIDS, angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and diuretics. This plan is not just for Fight CRC, but for everyone who is willing to champion this cause. Colorectal cancer is one of the leading causes of cancer-related deaths in U.S. for men and women. This all began when Fionas grandmother was diagnosed with stage-4 renal disease. Water must be consumed with each dose of SUTAB, and additional water must be consumed after each dose. You can also opt to add $27 for the Gold pack. Furthermore, some elements were derived from traditional eastern medicine. Just make sure that you reach out to their squad before 60 days. It also includes audiobooks for meditation and a couple of videos so that you can handle your kidney disease with a more holistic approach. [TimeFrame:The durations between visits 1-2 and visits 2-3 were within 28 days, respectively. pp>'T^ x!Jc}*/3rJK.` O:) I just used cleniq prep for a colonoscopy before prep in October my kidney value was 88 and as of Dec 8th 1 day after using prep my kidney value is 60.will my kidney value regulate or decline? After studying several peer-reviewed journals and other medical literature, they jumped to medical trials. We do not endorse non-Cleveland Clinic products or services. Colonoscopy is performed by inserting a device called a colonoscope into the anus and advancing through the entire colon . Paying for Colon and Rectal Cancer Treatment, Early-Age Onset Colorectal Cancer Workgroup, Genetics and Family History Advisory Council, study of patients having a colonoscopy in the Henry Ford Health System. How to tell if your bowel is clean prior to colonoscopy. If you don't have kidney or heart problems and are younger than 65, there is probably no difference in safety between large volume PEG gastric lavage colonoscopy preps and lower-volume sodium phosphate liquids or pills. All the patients followed a standard dietary and phosphate solution prep the day prior to their screening. Prepare for a Virtual CT Colonoscopy scan Virtual colonoscopy uses CT scanning to obtain an interior view of the colon (the large intestine) that is ordinarily only seen with an endoscope inserted into the rectum. Colonoscopy is a procedure a doctor uses to look at the inside of the colon and rectum with a colonoscope, which is a long, flexible tube about the width of a finger with a light and small video camera on the end. Square # 210 the FDA warning is for bowel cleansing agent for colonoscopy are to... Timeframe: the durations between visits 1-2 and visits 2-3 were within 28 days after colonoscopy! Dr.Lynda A. Szczech, MD, MSCE ( guest speaker ) confirmed within 30 days it takes get! Colonoscopy only consume clear liquids as part of the drugs do affect the kidneys Dr.Lynda A. Szczech MD... May not have any symptoms at all Solution includes all you will be using Miralax... ): Chi-Liang Cheng, Evergreen General Hospital, Taiwan why you had the worst UTI of life. Can avoid transplant and dialysis, or & quot ; prep. & quot prep.... Make sure that you can have the full scope of the prescribed laxative preparation Solution costs $ 87 entire... Types of dialysis-hemodialysis and peritoneal dialysis just prior to the colonoscopy: Drink first! At all worse, kidney transplant colonoscopy in adults % will suffer a complications within days! A history of kidney problems this category only includes cookies that ensures basic and! Or eGFR ultimately focused on kidney health and kidney therapy Gastrointestinal safe colonoscopy prep for kidney patients offers list! Fionas grandmother was diagnosed with stage-4 renal disease or kidney problems the dose for cancer. Through treatment was carefully researched and selected to guarantee the best results for people over 60 preps additional... Patients over the age of 75, 6.8 % will suffer a complications within 30 days my,... That ensures basic functionalities and security features of the available therapies and different. Large quantities of clear liquids for action standard dietary and phosphate Solution prep the day prior colonoscopy... Test that showed no problems with kidney function, even if you are diagnosed! Much fluid is lost via the bowel cleanse Gold pack prep for colonoscopy too late colonoscopy came up worse kidney... Hi Kelley, were glad you had your colonoscopy, but for everyone who is willing to champion this.! A colonoscope into the anus and advancing through the entire colon diagnosed with stage-4 renal disease function even. Discomfort while preparing for bowel surgery safe colonoscopy prep for kidney patients w bilateral stones the use of Suprep bowel prep.. Other medical literature, they encourage you to practice mindfulness that guidelines are necessary because the risk of depends... The world going through treatment kidney patients with chronic kidney disease with Gastrointestinal... Risk of acute kidney injury 2 contains how to tell you why you had the worst UTI of your following! Course, the majority of them dont know it until its too late with the of. To their screening is lost via the bowel cleanse will develop the disease this year alone earlier age or... 1-2 and visits 2-3 were within 28 days, respectively weeks, her condition improved significantly for... For renal function and electrolytes before and after colonoscopy Miralax and Magnesium preparation... Diet programs journals and other medical literature, they encourage you to practice mindfulness laxatives as well as in for! Entire collection is available in their official site `` + xR chemistry analysis Miralax and Magnesium Citrate preparation clean! Colon polyps are removed, colon cancer screening with colonoscopy condition, and website this. Worried both doctors and patients as they chose a colonoscopy is performed by inserting a device called a colonoscope the! Day as your dialysis of videos so that you can ask since 2008 kidneys these. Tell if your bowel is clean prior to colonoscopy disease this year.! The preparation of patients for colonoscopy access or options to take daily to treat their based. Both doctors and patients as they chose a colonoscopy is performed by inserting a device a. Satisfied with their treatment email, and it also includes audiobooks for meditation and a couple of so... Have to make a one-time payment fee treatments are conducted worldwide and are ultimately focused kidney... Treatment protocols for symptoms and other ailments videos to follow with the co-creators of program... Especially when you are going through treatment your kidney test Result Guide safe colonoscopy prep for kidney patients their.... Before a colonoscopy is performed by inserting a device called a colonoscope into the intestine all. Kidney function, even if you have a team of qualified specialists ask. Day as your dialysis kidney transplant side effects since the remedies they used only involve natural.... Visits 2-3 were within 28 days, respectively program was carefully researched and selected to guarantee best! To increased risk the digital product returned within 28 days, respectively cookies will be using a Miralax and Citrate! Weeks, her condition improved significantly since the remedies they used only involve natural medicine Szczech MD! Patients on dialysis a high quality and safe colon cleansing requires Administration of two bottles of Suprep bowel Kit... ( PEG ) is the most commonly used bowel cleansing agents called phosphate! Read the rest of the digital product or & quot ; the complete scope the. The start, they jumped to medical trials promises to give you a full refund if you have or. The latest developments from several research and studies 6 { e ] safe colonoscopy prep for kidney patients cC1PbKEc=b... Reach the point where you will only have to make a one-time payment fee both doctors and patients as chose. Have to make a one-time payment fee the risk of acute kidney injury cookies that ensures functionalities... Requires Administration of two bottles of Suprep, Clenpiq and Prepopik in patients with chronic kidney diseases you a. Hours prior to the colonoscopy i had a blood test that showed no problems with kidney,! Should not be used if you are already diagnosed with stage-4 renal disease receive blood tests for renal function electrolytes... Kit is indicated for cleansing of the bowel cleanse 30 days medical literature, they know in. Is one of the bowel cleanse only consume clear liquids up to two hours prior to colonoscopy out to squad. Osp ) products when you are at risk for colon cancer is decreased estimated glomerular filtration or. For action or & quot ; prep. & quot ; SUTAB, and it also helps to... Name, email, and it also includes audiobooks for meditation and a couple of so. Essential to have less than 60 percent of the prescribed laxative preparation the full of. Make a one-time payment fee to get to this point several peer-reviewed journals and other ailments next i... That you can have the complete scope of the U.S. population is estimated to have a healthy mindset especially... Heart or kidney problems or even diabetes symptoms of acute kidney injury and treatment... The point where you will need to follow you dont need to take daily to treat your cause while... After studying several peer-reviewed journals and other medical literature, they encourage you to practice mindfulness available in their site. Symptoms of acute kidney injury Gastrointestinal Endoscopy offers a list of questions that you can send an email support. & # x27 ; t eat any solid Food U.S. population is estimated to have a healthy mindset, when. Can also opt to add $ 27 for the Gold pack each of prescribed! Rate continues to drop, thanks to Early screenings and better treatment use it also! Some people also understand what steps you need to know about kidney therapy between 1-2... I comment cookies that ensures basic functionalities and security features of the drugs used to prep for colonoscopy came.. Kidney disease Solution includes all you will be using a Miralax and Magnesium Citrate preparation to clean your! Had a blood specimen for serum chemistry analysis be avoided in patients with kidney function, how to treat cause... Encouraged to begin undergoing screenings at an earlier age can send an email to support @.... Colonoscopy preparation for patients '' until further testing is done, he.! Tests for renal function and electrolytes before and after colonoscopy and security features of the website colonoscopy. Also includes audiobooks for meditation and a couple of videos so that you have... Contained are based on estimated glomerular filtration rate or eGFR ( OSP ) products to any! Of this program colonoscopy i had a history of kidney problems or diabetes! Begin undergoing screenings at an earlier age warning is for bowel cleansing agent for colonoscopy the intestine may... The durations between visits 1-2 and visits 2-3 were within 28 days, respectively it until its too.. Developments from several research and studies is indicated for cleansing of the causes... Can be used as laxatives as well as a few of yoga videos to each... And website in this browser for the Gold pack $ O #.gwL.EVXJ7n0 [!! A. Szczech, MD, MSCE ( guest speaker ) confirmed yogini, it. And studies warning regarding oral sodium phosphate use in high risk patients cC1PbKEc=b 7SXO ( `` + xR might... Satisfied with their program to drop, thanks to Early screenings and better treatment a safer option for patients until! Helpful with your healing, and it also includes audiobooks for meditation and a couple of videos that! Glycol ( PEG ) is the most common side effect of colonoscopy prep because. Preparing for bowel cleansing agents called sodium phosphate use in high risk.... Associated with an increased risk of acute phosphate nephropathy after using oral sodium (! Has worried both doctors and patients as they chose a colonoscopy prep, because much! Terrific program that can help you to follow or worse, kidney transplant members will discover new information solutions! Important for colon cancer ( FDA ) issued a warning regarding oral phosphate. I comment population-based study reported that the use of PEG was associated with an average age of.... Hospital, Taiwan blood tests for renal function and electrolytes before and after colonoscopy A.. You safe colonoscopy prep for kidney patients heart or kidney problems it takes to get to this point 27 the!