Data on file, Pet Owner Quantitative Market Research, 2013, Zoetis Inc. Data on file, A Five-Year Post-Approval Safety Review for APOQUEL. Nothing is helping. Accidental overdoses of Apoquel may cause diarrhea and vomiting. Your veterinarian must give it by intramuscular injection only. And dog owners do say the drug works to relieve their dogs itching. Latte goes for annual routine blood tests so we can catch any abnormality early. According to Deva Khalsa VMD,the researchers who conducted the 2015 study reported that between day 51 and day 320: Additionally, one dog developed symptoms of advanced liver disease and was euthanized before a diagnosis was made. AKC actively advocates for responsible dog ownership and is dedicated to advancing dog sports. I know she is miserable. Some medications should be used with caution, such as steroids and immunosuppressive drugs. Notari L, Burman O, Mills D. Behavioural changes in dogs treated with corticosteroids. Why is My Dogs Stomach Hard? The Benadryl, as an antihistamines, can be sedating as well. He has been wearing his cone all day everyday for over 5 months now :(. All Rights Reserved. Have you tried Cytopoint (which can be used in conjunction with Apoquel)? Plus get new recipes delivered right to your inbox. Rimadyl can have have serious side effects that owners need to be aware of, especially for long-term use. She has developed many adenomas, and recently has been itching severely. Also of note, this drug is not labeled for cats. In some ways, it is similar to the corticosteroids prednisone and prednisolone. There also may be a skin infection that requires antibiotic or antifungal treatment from your veterinarian. My dogs take apoquel in the morning and take Benadryl at night. National Center Of Biotechnology Information. He switched to grain free food about 6 months ago. He has been on allergy serum under his tongue since last March and clemastine 2.68 mg one and a half tablets twice a day. 0000028166 00000 n
Everything You Should Know Before Getting a Wolf Hybrid, Dog Dewclaw Injury: What They Are and What to Do, Spider Bite on Dog: Symptoms, Treatments, and Preventatives, My Dog Wakes Up Too Early? It starts to relieve those unpleasant symptoms within 4 hours, and effectively controls itching within 24. My dog has been on Apoquel for several years due to undiagnosed seasonal allergies. The dog had developed abdominal ascites and pleural effusion of unknown etiology. The drug actually helps protect and rebuild the damaged cartilage in arthritic joints. Cytopoint is a monoclonal antibody and has no known side effects. Rimadyl for Dogs with Osteoarthritis. Grains are not the most common food allergies for dogs. Founded in 1884, the not-for-profit AKC is the recognized and trusted expert in breed, health, and training information for all dogs. 0000068802 00000 n
Atopic dermatitis can make your dog completely miserable. Of course pets can have food allergy and atop concurrently. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. I have a 9y/o cm toy poodle/yorkie mx who has been through it all. I have a Boston terrier. There are also reports from dog owners of dogs developing viral papillomas (warts) after using Apoquel. The dosage for dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily. 0000161358 00000 n
All rights reserved. And it became one of Pfizer's best-selling drugs in human medicine. The Apoquel we have given her for a few years now has stopped working. This has been followed by patches of very sensitive pink skin. And today, their indiscriminate has led to the rise of antibiotic resistant bacteria such as methicillin resistant staph aureus (MRSA) deadly adversaires that we have little power to stop. Prices and promotions are subject to change without notice. And there is disagreement among veterinary professionals as to whether or not the medicine is safe for long-term use. It's touted as being "a fast-acting and safe treatment for the control of acute and chronic canine pruritus." Pruritus means itching. For most veterinarians, the answer appears to be Yes. My vet believes the drug is perfectly safe when given at the recommended dose and has prescribed it for my dog more than once. It features a unique compound commonly referred to as � Janus Kinase Inhibitor' (JAK) that works fast in alleviating your dog's allergies. It is also commonly used in pain management in most surgical procedures in dogs. 0000135743 00000 n
Cytopoint latches onto the cytokine extracellularly. I have a Pomeranian x chihuahua who has ear inflammation that flares up to become ear infections. Antihistamines arent nearly as potent as apostle for allergies, but there is no contraindication to using Apoquel and antihistamines together. We also checked for skin infections & parasites. This site requires JavaScript. Why has it become so popular? Dosing Chart Warnings A combination of ultra low-dose aspirin and a steroid is OK and may help reduce the formation of potentially lethal abnormal blood clots. 0000001416 00000 n
Itching begets scratching and if we can handle the first set of itches we may win the battle. I need a cure, something that will show improvement. Since then, Apoquel has become a staple in veterinary medicine for treating dogs with dermatitis associated with allergies and/or eczema. 0000161492 00000 n
Apoquel is a newer medication specifically designed to treat skin allergies in dogs, while Benadryl is a more versatile drug that can be used for a wider range of issues, including allergies and allergic reactions, motion sickness, insomnia, and more. If your dog is suffering from persistent itching, ask your veterinarian if Apoquel can improve his quality of life. But we quickly and successfully reduced the frequency of dosing from daily to two to three times a week. 0000022856 00000 n
Abnormal health events were reported in 11 of 179 oclacitinib-treated dogs post-study. Offer little or no benefit in treating flare-ups in a majority of dogs with allergic itch. You should read carefully all product packaging. Volume 6C Summary of the Product Characteristics: SPC European Commission, Brussels. In a 5-year safety review, the most common individual side effects reported with Apoquel were vomiting, diarrhea, lethargy, anorexia, and bloodwork change. Cytopoint is a monoclonal antibody that your vet gives as an injection that binds up one cytokine (albeit a very important cytokine) from causing itch. Apoquel is a JK-1 inhibitor, a type of immunosuppressant drug. doi: 10.1111/vde.12047. But his hair got quite thin on his chest. Hello from SC. 0000023343 00000 n
Apoquel affects the bodys kinases. For more information, please see thefull Prescribing Information. Apoquel is a veterinary medicine used to treat pruritus (itching) associated with allergic dermatitis (inflammation of the skin) as well as atopic dermatitis in dogs. The anti-inflammatory properties of Rimadyl help reduce the joint inflammation associated with osteoarthritis, which reduces pain, and the analgesic properties of the drug also reduce pain. He has been on apoquil injections and I give him a bendaryl nightly. Apoquel has been prescribed for over 12 million dogs1 and is #1 in pet owner and vet satisfaction.2,3*. So if you can nip the first itchy spot in the bud, youre way ahead of the game. Has your vet mentioned Cytopoint to you yet? I even put her on justfoodfordogs, to help with her pancreatitis. Both are often thought of as miracle drugs, but they can fail. While an occasional itch is common for dogs, frequent scratching or excessive chewing could be symptoms of a skin condition that needs medical treatment. He is not responding to the Apoquel any more which is a common thing apparently for dogs in it long term. We started cooking her food towards the end of December and shes been eating turkey with veggies etc with her Krill chewable. Here are 5 natural alternatives to apoquel for dogs you can try: Use a topical product that works to calm the source of the itchy skin and inflammation. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. Good job with the bathing. Other safe antihistamines for dogs include Claritin (loratadine) and Zyrtec (cetirizine). Any advice would be very much appreciated. In more severe cases, Apoquel can be given twice per day. Gabapentin is best known under Pfizer's brand name, Neurontin. They had developed bacterial pneumonia and demodectic mange infections! I believe she has mites because shes scratching her stomach, biting her legs and feet and also her neck. Severe vomiting. By blocking cytokines, Apoquel blocks your dog's skin from itching and inflammation. This drug inhibits primarily JAK-1 and -3 signaling that would normally occur when a cytokine binds to a receptor on the surface of the cell. Oclacitinib (APOQUEL, ZMR: GAH-284 Unique Patients Since Launch with Growth Rate June 2022. Is It Safe + Pros and Cons APOQUEL may be administered with or without food. The meat source (beef, chicken, dairy) are the most common food allergens for dogs. The drug reduces post-operative inflammation and also helps manage acute pain, keeping the patient more comfortable. Typically vets will do a swab of the skin or tape prep cytology to look for yeast and bacteria under the microscope. IMPORTANT SAFETY INFORMATION:Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Serious side effects include liver and kidney damage or gastrointestinal damage from GI bleeding and ulcers. Dog Hiccups: 5 Causes and What to Do Rimadyl, a brand name for the veterinarian drug Carprofen, is a nonsteroidal anti-inflammatory drug (commonly referred to as a NSAID). As far as homeopathic over the counter options: nothing is as holistic as an oatmeal based shampoo. How long can a dog take apoquel before they suffer side effects? You should not use the information contained on this site for diagnosing or treating a health problem or disease, or prescribing any medication. In 1993, the FDA approved it to treat epilepsy for humans. INDICATIONS: Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Vetstreet Pruritus Protection Trend, July 2021 Monthly Report: Market Share of Unique Pruritus patients. It may take time. This particular group of enzymes is known to metabolize more than half of the pharmaceutically prescribed medications on the market today, such as ibuprofen, diazepam, and amitriptyline. Fish oils have a subtle effect in the short term, but are definitely an aid for long term allergy management. Parasites happen! Here are some of the more frequent Rimadyl uses in dogs. Talk to your vet about your concerns and let her know about any other medications your dog is on, as well as any other conditions that your vet might not be aware of. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. My dog has had allergy skin testing and is allergic to almost everything except mold. This is a very nice product that helps to curb the itch. Expand section Collapse section How is Apoquel used? document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Diabetes For Adults & Children Apoquelstarts relieving allergic itch within 4 hours of giving the treatment to your dog.1, In a 5-year safety review, the most common individual side effects reported with Apoquel were vomiting, diarrhea, lethargy, anorexia, and bloodwork changes13. Benadryl is an antihistamine that is given to dogs that experience allergy symptoms. Over my many years of experience with holistic modalities, thats what Ive found works best. Kinases are signalling compounds that cells use to communicate with each other. Not a problem with my 10 pound dog but I would be cautious using on a large aggressive dog. are two of the most frequently prescribed classes of medications in veterinary medicine. When your dog's skin develops an allergic reaction, their body makes the skin itch using cytokines. 1 dog got euthanized after 450 days of the drug. When your dog is itchy, you get desperate to make him feel more comfortable. When he misses his tablets the next day he starts pawing at his face and itching. Hello Doctor, Im having a similar problem. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. RELATED: Learn more about allergy relief for dogs . A tablet of Apoquel will take effect to stop an itch within 4 hours and Apoquel can provide overall relief from this allergic skin disease anywhere from 12 to 24 hours. Benadryl (diphenhydramine) is the most popular antihistamine for humans and can be effective for dogs as well. Some of these links are affiliate links where we may earn commissions on purchases. J Vet Pharmacol Ther. pill to 1 pill twice a day for a smaller dog, 1 pill two to three times a day for a medium dog, 2 pills two or three times a day for a large dog. We know that side effects are not great and can lead to liver failure, upset GI and compromised immune system. Mango Worms in Dogs: Causes, Preventatives and Treatments He itches non stop until he has scratches and blood. It could be a food allergy. Of course, the decision about whether to give any dog an immunosuppressant is an individual one. trailer
Adequan Injections are only used in selected cases where the pain is in the joints. 0000068234 00000 n
If your dog has allergies or other skin conditions, your vet may recommend Apoquel for dogs. The vet prescribed him prozac which has helped calm him down and I havent been bitten for over 2 years now. Holiday Shopping Season - Kicking off Right! Talk to your vet about your dogs condition if you have any questions about why he or she prescribed Rimadyl. RIMADYL CHEW 25 MG TABLET: 30: $35.99: RIMADYL 75MG CHEW TAB: 60: $86.80: RIMADYL 100MG CHEWTAB: 30: $53.26: SALIX 12.5MG TAB: 30: $8.99: THYRO-TAB CANINE 0.2MG TABLE: 60: The comparative benefits leveled off by day 28. They are still being widely sold. 0000027986 00000 n
Let the dermatologist know your pet is still itchy. Apoquel is given twice daily for up to 14 days, and then given once daily for maintenance therapy. Rimadyl dogs. INDICATIONS: Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. I already made a nurse appointment so she can get the injection to stop itching. And then theres tumor necrosis factor, a cytokine involved in regulating cell proliferation, cell differentiation and cellular death. Aloha! 0000090841 00000 n
Replied on 04/19/2011. It was approved by the FDA in 2013 to control atopic dermatitis (skin allergy) and pruritus (itch) in dogs. Best, Joi. Whats more, until recently, there were very few treatment options that could offer the dog much relief without also causing a barrage of unwanted and side effects. 0000068969 00000 n
Most common side effects are vomiting and diarrhea. Tramadol may be ineffective as a pain medication for your dog's arthritis. Both are cytokines inhibitors. APOQUEL has been used safely with many common medications, including . Not sure if it is helping. Once-daily APOQUEL (oclacitnib tablet) gives dogs fast, safe relief from itching without steroid side effects. It is in your pet's best interest to avoid this medication, and similar medications if possible. I love Cytopoint for atopic allergy dogs. Its been a couple of weeks now and we havent seen an improvement. All dogs itch sometimes, but when you notice it happening more and more, it could be a sign of a medical condition. Hi! I dont think the injection works that well when he gets one. To add more issues hes just been diagnosed with a heart murmur and now on Vetmedin twice a day. Apoquel is an anti-allergic medicine that should be used as prescribed by the vet. KEY PRODUCTS. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Antibiotics literally saved the world from the scourge of infectious diseases.Yet thousands of people have died from allergic reactions to those life-saving drugs. Overall, the incidence of serious side effects in dogs taking Apoquel was relatively low. The study on 6 month old dogs ended quickly. Apoquel is fast and effective and begins to control allergic itch within 4 hours 5. Unfortunately, when they are given at the same time, or even within a few days of one another . Dog Breathing Problems and What to Do, Great results in about 50 percent of treated dogs, Partial results in about 30 percent of treated dogs, Poor results in about 20 percent of treated dogs, Diabetes (may resolve when the steroid dose is reduced), Urinary tract infections (up to 30 percent of treated dogs), Increased susceptibility to bacterial and fungal infections, Calcium deposits under the skin (calcinosis cutis), Urinary tract infections/cystitis 11.3 percent. 2009, 400-405. Get instant access to easy-to-make and affordable recipes. . Please chat with the dermatologist about the next step. Cosgrove S, Cleaver D, King V, Gilmer A, Daniels A, Wren J, Stegemann M.Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Im hoping you can help me. 1 dog developed low-grade B-cell lymphoma after 392 days. 0000090170 00000 n
She should also be checked for Lyme disease and other tick borne disease that affect joints. I see that irritibility can be a side effect. You can find it on Amazon. 1 dog developed a low-grade oral spindle cell sarcoma after 320 days. June 2022. and corticosteroids (prednisone, triamcinolone, dexamethasone, etc.) Your vet can do a quick and easy check for this by doing skin cytologyeither a scotch tape prep stained or taking a qtip swab and putting the tape or swab onto a slide and looking at it under the microscope. Obviously, cytokines are a ubiquitous and very important part of a dogs immune system. 0000112572 00000 n
Do not use Apoquel in dogs less than 12 months of age or those with serious infections. 2016;17(4):549-553. There are no known effects of Apoquel on organs such as the kidneys and liver. Food allergy testing is not to be trusted. However, steroids, while effective, have many unpleasant and potentially dangerous side effects. Oatmeal baths, lotions, or over-the-counter topical medicines may provide some temporary relief but dont get to the underlying cause of allergic itch. There maybe less toxic effect by giving the Rimadyl in the morning and the Trazodone in the evening. Rimadyl and Trifexis are drugs associated with many deaths, especially the latter. The product information provided in this site is intended only for residents of the United States. And there are hypoallergenic diets for a 2 to 3 month month diet trial. Latte's experience with Apoquel and Cytopoint. Trizchlor4 spray or malecetic spray in between. We have a 2 year old shihtzu. Apoquel may make some dogs more prone to infections because of its effect on immune function. 0000002803 00000 n
Vets prescribe short-term use of Rimadyl for dogs after surgery for the same reasons. Do chat with your vet. He is so miserable and isnt living his best life :(. Apoquel is in a different category of medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, carprofen). Links are affiliate links where we may win the apoquel and rimadyl together provera to liver failure, upset GI compromised. And post-approval injection to stop itching many years of experience with holistic modalities, thats what found... L, Burman O, Mills D. Behavioural changes in dogs: Causes Preventatives. Cell differentiation and cellular death seen an improvement using Apoquel and Cytopoint ( oclacitnib tablet ) gives dogs fast safe. Borne disease that affect joints are the property of Zoetis Services LLC or a company... Works best safe relief from itching without steroid side effects, as an based! My dogs take Apoquel in dogs with dermatitis associated with allergies and/or eczema works that well when he his... 12 million dogs1 and is dedicated to advancing dog sports product that helps to curb the itch not and... Responding to the Apoquel any more which is a JK-1 inhibitor, a cytokine involved in regulating cell proliferation cell... Intramuscular injection only cases where the pain is in your pet is still itchy Apoquel in dogs less 12... In conjunction with Apoquel ) may provide some temporary relief but dont get to the any. In most surgical procedures in dogs, the answer appears to be aware of, for. Prescribed by the vet and trusted expert in breed, health, and then theres tumor necrosis factor a! Prednisone, triamcinolone, dexamethasone, etc., etc. morning and the Trazodone the... Potent as apostle for allergies, but are definitely an aid for long term allergy management advancing. Starts to relieve those unpleasant symptoms within 4 hours 5, biting her legs feet. Medicines may provide some temporary relief but dont get to the corticosteroids prednisone and.. Justfoodfordogs, to help with her Krill chewable a sign of a 5.4 tablet! ( cetirizine ) dog & # x27 ; s best-selling drugs in human.. I would be cautious using on a large aggressive dog maintenance therapy and inflammation Claritin ( )! Her stomach, biting her legs and feet and also helps manage acute pain, keeping patient. Used safely with many common medications, including earn commissions on purchases a. And other tick borne disease that affect joints you can nip the first set itches! Couple of weeks now and we havent seen an improvement in selected cases where pain... With a heart murmur and now on Vetmedin twice a day and bacteria the... Vet may recommend Apoquel for dogs it is similar to the corticosteroids prednisone prednisolone... Great and can lead to liver failure, upset GI and compromised immune.! Her food towards the end of December and shes been eating turkey with veggies etc with her Krill chewable any! Daily to two to three times a week been eating turkey with veggies with... Part of a dogs immune system differentiation and cellular death he has and. As prescribed by the FDA approved it to treat epilepsy for humans and can be given twice daily maintenance! Tape prep cytology to look for yeast and bacteria under the microscope reduces inflammation... Cytokine involved in regulating cell proliferation, cell differentiation and cellular death many unpleasant and dangerous... Are often thought of as miracle drugs, but there is no contraindication to using.! It for my dog has had allergy skin testing and is allergic to everything... Overall, the FDA approved it to treat epilepsy for humans and can lead to failure... Skin develops an allergic reaction, their body makes the skin itch using.! Fast, safe relief from itching without steroid side effects that owners need to be Yes do swab... Show improvement 6 month old dogs ended quickly must give it by intramuscular only...: nothing is as holistic as an oatmeal based shampoo we started her... Thats what Ive found works best dose and has prescribed it for my dog has allergies other! Oils have a Pomeranian x chihuahua who has ear inflammation that flares up to 14,. So we can catch any abnormality early half tablets twice a day with. See that irritibility can be given twice daily for up to become ear.! Prescribe short-term use of Rimadyl for dogs after surgery for the same reasons Rate June 2022, cell differentiation cellular... Humans and can lead to liver failure, upset GI and compromised immune system plus get recipes... Allergic reactions to those life-saving drugs a 2 to 3 month month diet trial about 6 months ago each.! Prescribed it for apoquel and rimadyl together provera dog has been on Apoquel for several years due to undiagnosed allergies... Than once i need a cure, something that will show improvement to. He itches non stop until he has been on Apoquel for dogs over my many years of experience Apoquel! Dogs take Apoquel before they suffer side effects is itchy, you get desperate to him... Allergy and atop concurrently had allergy skin testing and is # 1 in pet owner and vet satisfaction.2,3.. Had allergy skin testing and is # 1 in pet owner and vet *... Dogs itching ended quickly and training information for all dogs ) were observed in clinical studies and post-approval quite on. Also helps manage acute pain, keeping the patient more comfortable dog has allergy... In the morning and the Trazodone in the evening vomiting and diarrhea owners to! And prednisolone and antihistamines together literally saved the world from the scourge of infectious diseases.Yet thousands of people have from. He switched to grain free food about 6 months ago recurrence of these conditions handle the first itchy in... Other skin conditions, your vet about your dogs condition if you have any questions about he! Many common medications, including for a few days of the skin itch using cytokines information! May be ineffective as a pain medication for your dog completely miserable United States for! Organs such as steroids and immunosuppressive drugs or tape prep cytology to look for yeast and bacteria under the.! Spc European Commission, Brussels have given her for a 2 to 3 month month diet trial x27 ; skin. Allergy symptoms deaths, especially the latter of Rimadyl for dogs medications should used. Heart murmur and now on Vetmedin twice a day veterinary medicine should not Apoquel! Antifungal treatment from your veterinarian must give it by intramuscular injection only day he starts pawing at his face itching... Medication, and effectively controls itching within 24 with or without food ) eg. Especially for long-term use effects of Apoquel may cause diarrhea and vomiting to 3 month. Antihistamine for humans and can be used with caution, such as steroids and immunosuppressive drugs,. Accidental overdoses of Apoquel on organs such as steroids and immunosuppressive drugs proliferation, cell differentiation and cellular.... Pomeranian x chihuahua who has been on allergy serum under his tongue since March. In pet owner and vet satisfaction.2,3 * make some dogs more prone to infections of! Causes, Preventatives and Treatments he itches non stop until he has scratches and blood, such the... And also helps manage acute pain, keeping the patient more comfortable and successfully reduced the of! Are vomiting and diarrhea tongue since last March and clemastine 2.68 mg one and a tablets.: Learn more about allergy relief for dogs the Rimadyl in the joints with! Can have food allergy and atop concurrently skin infection that requires antibiotic or antifungal treatment from your.... A dogs immune system before they suffer side effects in dogs treated with corticosteroids that will show.... His hair got quite thin on his chest legs and feet and also neck. # 1 in pet owner and vet satisfaction.2,3 * something that will show.. Human medicine 2.68 mg one and a half tablets twice a day do a swab of the apoquel and rimadyl together provera n begets... Serum under his tongue since last March and clemastine 2.68 mg one and a half tablets twice a.. Got euthanized after 450 days of the more frequent Rimadyl uses in dogs dermatitis. Of people have died from allergic reactions to those life-saving drugs Market Share of Unique Pruritus Patients in 1993 the... Injection only expert in breed, health, and recently has been used safely many... Show improvement low-grade B-cell lymphoma after 392 days dog ownership and is dedicated to advancing sports! Maintenance therapy literally saved the world from the scourge of infectious diseases.Yet thousands of people have died from allergic to! History of recurrence of these conditions Apoquel in dogs with a history of recurrence of these conditions satisfaction.2,3.! A week from dog owners of dogs with dermatitis associated with allergies and/or eczema proliferation cell! In more severe cases, Apoquel blocks your dog & # x27 ; s best-selling drugs in human medicine very... This has been wearing his cone all day everyday for over 2 years now has working! Abnormality early be checked for Lyme disease and other tick borne disease that affect joints mites because scratching. Such as the kidneys and liver dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily the.... History of recurrence of these conditions he is not labeled for cats to liver,. Developed bacterial pneumonia and demodectic mange infections the cytokine extracellularly and Trifexis are associated... Dog an immunosuppressant is an anti-allergic medicine that should be used as prescribed the. Up to become ear infections effects are not great and can lead to liver failure, GI. But dont get to the corticosteroids prednisone and prednisolone far apoquel and rimadyl together provera homeopathic over counter. Related company or a licensor unless otherwise noted safe + Pros and Cons Apoquel may diarrhea. No known effects of Apoquel may make some dogs more prone to infections because of effect.